In today’s globalized economy, logistics and supply chain management (SCM) are critical to maintaining competitiveness, reducing costs, and ensuring customer satisfaction. However, inefficiencies such as delayed deliveries, excess inventory, and poor resource utilization often hinder optimal performance. Lean Six Sigma (LSS)—a hybrid methodology combining Lean principles (focused on waste reduction) with Six Sigma (focused on process variation reduction)—can significantly enhance logistics and supply chain processes. This article explores the application of Lean Six Sigma in logistics and SCM, detailing its benefits, implementation strategies, and real-world examples of success.