In today’s competitive business landscape, organizations are continuously seeking ways to improve quality, reduce waste, and enhance customer satisfaction. Two of the most powerful methodologies in achieving these goals are ISO 9001 and Lean Six Sigma. While ISO 9001 provides a robust framework for establishing quality management systems (QMS) based on internationally recognized standards, Lean Six Sigma offers a data-driven approach to process improvement. Integrating these methodologies can yield significant operational benefits, ensuring that quality management not only meets compliance requirements but also drives continuous improvement and efficiency. This comprehensive article explores the principles of ISO 9001 and Lean Six Sigma, explains the benefits of their integration, outlines strategies for a successful merge, and discusses practical examples and potential challenges.