In today's highly competitive and regulated global market, organizations face increasing pressure to optimize operations, enhance quality, and meet regulatory standards. Achieving these goals requires a strategic approach that combines operational efficiency with robust quality management systems. Integrating Lean Six Sigma (LSS) with ISO Management Systems offers a powerful framework for achieving quality excellence by streamlining processes, reducing waste, improving product or service quality, and ensuring compliance with international standards. This article explores the synergies between Lean Six Sigma and various ISO management systems, such as ISO 9001 (Quality Management), ISO 14001 (Environmental Management), ISO 45001 (Occupational Health and Safety), and ISO 22000 (Food Safety), and outlines a roadmap for successful integration.